Teruel Lab

Signaling Control of Cell Differentiation

Publications

TGF-beta converts post-mitotic adipocytes into proliferating myofibroblasts through synergistic repression of PPARG expression and increased mechanical stress

Bielczyk-Maczynska E, Taylor B, Tan S, Zhao ML, Miller C, Dunn AR, and Teruel MN.  (in preparation)

A core component of mature adipocytes enforces cell identity by mediating adipocyte differentiation

Bahrami-Nejad Z, Tholen S, Zhao ML, Bielczyk-Maczynska E, Kraemer FB, and Teruel MN. (in preparation)

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Expression variation and covariation impair analog and enable binary signaling control

Kovary KM, Taylor B, Zhao ML, and Teruel MN. (2018). Molecular Systems Biology 14 (5): e7997. [Pubmed]

Diagram One

A transcriptional circuit filters oscillating circadian hormonal inputs to regulate fat cell differentiation

Bahrami-Nejad Z*, Zhao ML*, Tholen S, Hunerdosse D, Tkach KE, van Schie S, Chung M, and Teruel MN. (2018). *equal contribution, Cell Metabolism Apr 3; 27(4):854-868.e8. [.pdf file ] [Pubmed] 

Highlighted in Nature, ScienceNews, Stanford Medicine News, ABC News, NBC news, El comercio, the Los Angeles Times, The Times (London), NIH Research Matters

Received the inaugural Diabetes Knowledge Advancement (DKA) Award given by the Stanford Diabetes Research Center to the most impactful, original diabetes-related research publication from Stanford (2017-2018).

Diagram One

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide.

Shi Z, Fujii K, Kovary KM, Genuth NR, Rost HL, Teruel MN, Barna M. (2017). Molecular Cell Jul 6;67(1):71-83.e7. [Pubmed]

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A dynamic picture of protein behavior in cells.

Teruel MN, Gu B, Zhao ML. (2015). Nature Biotechnology Apr 7;33(4):356-7. [Pubmed]

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Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry.

Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R. (2015). Methods Mol Biol. 1322:105-23. [Pubmed]

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Using SRM mass spectrometry to quantify nuclear protein abundance differences
between adipose tissue depots of insulin-resistant mice.

Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN  (2015). Journal of Lipid Research May; 56(5): 1068-78. [Pubmed]

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Controlling low rates of cell differentiation through noise and ultra-high feedback.

Ahrends R, Ota A, Kovary KM, Kudo T, Park BO, Teruel MN. (2014). Science Jun 20; 344:1384-9. [PubMed]

Awarded an “Editors’ Choice” rating by the Science Magazine signaling editors and has been featured in SCOPE, the Stanford School of Medicine online Blog. Click here to view the Editors’ Choice and SCOPE writeups.

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Gli protein activity is controlled by multi-site phosphorylation in vertebrate Hedgehog signaling

Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. (2014). Cell Reports Jan 16; 6(1):168-81.[PubMed]

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The Proteome of Cholesteryl-ester-enriched Versus Triacylglycerol-enriched Lipid Droplets.

Khor VK, Ahrends R, Lin Y, Shen W, Adams CM, Nomoto A, Cortez Y, Teruel MN, Azhar S, Kraemer FB. (2014). PLoS One Aug 11; 9(8):e105047. [Pubmed]

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The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates

Chu BW, Kovary KM, Guillaume J, Chen L, Teruel MN, Wandless TJ. (2013). J. Biol. Chem.  Nov 29; 288(48):34575-87. [PubMed]

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Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion.

Park BO, Ahrends R, Teruel MN. (2012). Cell Reports Oct 25; 2(4):976-90. [PubMed]

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Neuropilins are positive regulators of Hedgehog signal transduction.

Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP. (2011). Genes Dev 25(22):2333-46.[PubMed]

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Parallel adaptive feedback enhances reliability of the Ca2+ signaling system.

Abell E, Ahrends R, Bandara S, Park BO, Teruel MN. (2011). Proc. Natl. Acad. Sci. U.S.A. 108(35):14485-90.[PubMed]

Awarded a “Must Read” and “Exceptional” rating by the Faculty of 1000.

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Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.

Park WS, Heo WD, Whalen JH, O’Rourke NA, Bryan HM, Meyer T, Teruel MN. (2008). Mol. Cell 30(3):381-92.[PubMed]

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siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.

Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T. (2007) Genome Biol. 8(7):R142. [PubMed]

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Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE. (2007) Cell Metab. 5(4):293-303.[PubMed]

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Fluorescence imaging of signaling networks.

Meyer T, Teruel MN. (2003). Trends Cell Biol. 13(2):101-6.[PubMed]

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Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy.

Tengholm A, Teruel MN, Meyer T. (2003). Sci. STKE 2003(169):PL4.[PubMed]

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Control of astrocyte Ca(2+) oscillations and waves by oscillating translocation and activation of protein kinase C.

Codazzi F, Teruel MN, Meyer T. (2001). Curr. Biol. 11:1089-97. [PubMed]

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Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.

Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD, Meyer T, Grinstein S. (2000) J. Cell Biol. 151(7):1353-68. [PubMed]

Diagram One

Spatial sensing in fibroblasts mediated by 3′ phosphoinositides.

Haugh JM, Codazzi F, Teruel M, Meyer T. (2000). J. Cell Biol. 151:1269-80. [PubMed]

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Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction.

Teruel MN, Meyer T. (2000). Cell 103:181-4. [PubMed]

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Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.

Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. (2000). Nature Neuroscience 3:881-6. [PubMed]

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Differential codes for free Ca(2+)-calmodulin signals in nucleus and cytosol.

Teruel MN, Chen W, Persechini A, Meyer T. (2000). Current Biology 10:86-94. [PubMed]

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A versatile microporation technique for the transfection of CNS neurons.

Teruel MN, Blanpied T. Shen K., Augustine GJ, Meyer, T. (1999). J. Neuroscience Methods 93: 37-38. [PubMed]

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CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIalpha/beta hetero-oligomers to dendritic spines.

Shen K, Teruel MN, Subramanian K, Meyer T. (1998). Neuron 21: 593-606. [PubMed]

Diagram One

GFP-tagged cysteine-rich domains from Protein Kinase C as fluorescent indicators for diacylglycerol signaling in living cells.

Oancea E, Teruel MN, Quest AFG, Meyer, T. (1998). J. Cell Biology 140: 485-498. [PubMed]

Diagram One

Electroporation-induced formation of individual calcium entry sites in the cell body and filipodia of adherent cells.

Teruel MN, Meyer T. (1997). Biophys. J. 73: 1785-1796. [PubMed]